When an unemployed divorced loser father Larry Daley is hired as night watchman at the Museum of Natural History, he soon discovers that an ancient curse brings all the exhibits to life after the sun sets. Suddenly, Larry finds himself face-to-face with a frisky T. rex skeleton, tiny armies of Romans and cowboys and a mischievous monkey who taunts him to the breaking point. But with the big help of President Teddy Roosevelt, Larry may just figure out a way to control the chaos and become a hero in his son’s eyes. Then when the three other evil night watchmen steal the tablet Larry must restore order to the museum before all the historic characters turn to dust!