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Three years ago in Mexico, determined Federale Machete (Danny Trejo) is betrayed and set-up by his boss, resulting in his wife and child being murdered by drug kingpin Torrez (Steven Seagal). Now, in Texas, Machete resurfaces when hired to assassinate Senator McLaughlin (Robert De Niro), an extreme advocate against illegal immigration. Once again betrayed and set-up, Machete plots his revenge against the men who’ve wronged him with the help of resistance fighter Luz (Michelle Rodriguez), ICE Agent Sartana (Jessica Alba), and the shotgun-toting Padre (Cheech Marin).