Sheldon (Jim Parsons) and Leonard (Johnny Galecki) know quantum physics and the Klingon language. They don’t, however, have a clue about women. That’s too bad, because attractive, newly single Penny (Kaley Cuoco) just moved into the building, and she could use some companionship. If these two nerds are ever going to score with the ladies, Penny will need to give them a crash course in life in this sitcom from the creator of ``Two and a Half Men.``