Lloyd Christmas is a loser taxi driver, who tries to return a suitcase which contains a lot of money to its owner, a beautiful woman named Mary Swanson who he took in his taxi to the airport, earlier. He must give her back the suitcase, and for that he goes with his dumb partner, Harry Dunne to a snowy town named Aspen. But a pair of criminals who wants the money try to follow them and to steal the money in the suitcase. Moreover, Harry and Lloyd both fall in love with Mary, and they struggle each other to win her heart.